AinaDara — Vancomycin TDM Calculator

Population PK → recommends starting dose & loading dose. Switch to Steady State Trough once a steady-state level is available.

Patient Demographics

Age

Sex

Total Body Weight

Height

Saved Profiles

Profiles are stored in this browser only (localStorage). Use de-identified labels — do not enter patient names, MRNs, or other PHI.

Amputation affects weight-based dosing and CrCl

Renal Function

Serum Creatinine

mg/dL

Measured value is used as entered — not rounded up.

Cystatin C · optional

mg/L

Enter when available — flags creatinine/cystatin discordance in low muscle mass.

Dosing Weight for CrCl

Cockcroft-Gault • AdjBW auto if TBW >20% above IBW

Set CrCl manually override the estimate, or run a what-if

mL/min

Baseline SCr (optional — for AKI detection)

mg/dL

Known AKI

Regimen Preferences

Preferred Interval

Infusion Duration

Standard: 1g/hr

Dose is auto-calculated from population PK. Interval suggestion based on CrCl shown above.

Loading Dose

Calculates a loading dose to hit target peak. Uses Vd×1.25 — distribution volume is larger at therapy start

Target peak concentration

mg/L

Time to first maintenance dose

From start of LD infusion · leave blank to match dosing interval

PK Model

Clearance Model

Volume of Distribution Model

Therapeutic Target

Trough Target Range

min

max

mg/L — default 10–20; severe infections 15–20

MIC (for AUC:MIC)

mg/L

Results

Enter the patient's demographics and renal function, then press Calculate Regimen.

Population PK — CrCl, clearance, volume, half-life
A maintenance regimen against an AUC₂₄ of 400–600 mg·h/L
The predicted steady-state curve, with peak, trough and target band

Bayesian Precision Dosing

Buelga 2005 · 1-compartment

Model

ICU / Critically Ill / Complex PK (favors 2-comp Goti model)

Saved Profiles

Profiles are stored in this browser only (localStorage). Use de-identified labels — do not enter patient names, MRNs, or other PHI.

Patient Demographics

Age

Sex

Total Body Weight

Height

Renal Function

Serum Creatinine

mg/dL

Cockcroft-Gault · AdjBW auto if TBW >20% above IBW · Used as fallback if no serial SCr entries below

Serial SCr — Time-Varying Renal Function (optional)

SCr (mg/dL)	Date & Time
No SCr entries — Bayesian uses baseline SCr above

When entries are present, Bayesian uses the SCr closest in time to the last dose. Enables AKI/recovery trend detection.

Dosing Course History

Doses Administered

Dose (mg)	Inf (h)	Date & Time
No doses — press + Add Dose

Current intended regimen

Detection runs when you calculate.

Observed Vancomycin Levels

Conc (mg/L)	Date & Time
No levels — press + Add Level

Levels can be drawn at any time point (not restricted to trough). More levels → narrower AUC uncertainty.

Therapeutic Target

AUC₂₄ Target

mg·h/L

MIC

mg/L

ASHP/IDSA 2020: AUC₂₄ 400–600 mg·h/L · AUC/MIC ≥ 400 at MIC 1 mg/L

Results

Enter the patient, the dosing history and any measured levels, then press Run Bayesian Analysis.

An individualised fit — MAP Bayesian, against the chosen population prior
AUC₂₄ with its uncertainty, and how far the fit moved from the prior
The concentration-time profile with your measured levels on it

Levels are optional — without them this is the population estimate.