AinaDara — Vancomycin TDM Calculator

Population PK → recommends starting dose & loading dose. Switch to Steady-state trough once a steady-state level is available.

Patient demographics

Age

Sex

Total Body Weight

Height

Saved profiles

Profiles are stored in this browser only (localStorage). Use de-identified labels — do not enter patient names, MRNs, or other PHI.

Amputation affects weight-based dosing and CrCl

Renal function

Patient receives intermittent haemodialysis

Serum Creatinine

mg/dL

Measured value is used as entered — not rounded up.

Cystatin C · optional

mg/L

Enter when available — flags creatinine/cystatin discordance in low muscle mass.

Dosing Weight for CrCl

Cockcroft-Gault • Auto uses AdjBW when TBW is >20% above IBW

Set CrCl manually override the estimate, or run a what-if

mL/min

Baseline SCr (optional — for AKI detection)

mg/dL

Known AKI

Regimen preferences

Preferred Interval

Infusion Duration

Standard: 1g/hr

Dose is auto-calculated from population PK. Interval suggestion based on CrCl shown above.

Loading dose

Calculates a loading dose to hit the target peak, using the selected model's volume and an infusion time sized to the loading dose

Target peak concentration

mg/L

Time to first maintenance dose

From start of LD infusion · leave blank to match dosing interval

Two levels — Sawchuk-Zaske

Use when CrCl is unreliable (bedbound, AKI, obese). Two post-infusion levels determine individual Kel and Vd directly.

Where in the course were these levels drawn?

Elimination is the same either way; volume is not. Levels drawn at steady state include drug already in the body, and treating them as first-dose levels understates Vd by roughly a third and overstates AUC₂₄ by about half.

Dose given

Infusion Duration

Dose start time

Level 1

Concentration

mg/L

Drawn at

Level 2

Concentration

mg/L

Drawn at

Target maintenance interval

Dose will be auto-calculated to target AUC 400–600 mg·h/L

Peritoneal dialysis

PD schedule

PD has stopped (catheter out)

Vancomycin before the first dose below?

Residual urine output

Also receiving intraperitoneal vancomycin

Dosing weight and volume

Weight now is the Total Body Weight above (actual body weight).

Weight at the load, if different

Volume of distribution

Goal level

Or a range of your own

min

max

mg/L. Presets: the 2009 consensus trough ranges (Rybak 2009). No goal, no answer.

IV doses

Levels

Give the next dose at (optional; blank means now)

24 h

Your settings (this browser)

Kept in this browser only, never part of the app. Use them for your institution's numbers.

Maximum single dose

Target peak, to compare

mg/L

AM labs drawn at (06:00 if blank)

24 h

PK model

Clearance Model

Volume of Distribution Model

Therapeutic target

Trough Target Range

min

max

mg/L — default 10–20; severe infections 15–20

MIC (for AUC:MIC)

mg/L

Results

Enter the patient's demographics and renal function, then press Calculate Regimen.

Population PK — CrCl, clearance, volume, half-life
A maintenance regimen against an AUC₂₄ of 400–600 mg·h/L
The predicted steady-state curve, with peak, trough and target band

Decision support and education only — not clinically validated, and not a prescription. Clinician judgment required.

Bayesian precision dosing

Buelga 2005 · 1-compartment

Model

ICU / Critically Ill / Complex PK (favors 2-comp Goti model)

Saved profiles

Profiles are stored in this browser only (localStorage). Use de-identified labels — do not enter patient names, MRNs, or other PHI.

Patient demographics

Age

Sex

Total Body Weight

Height

Renal function

Serum Creatinine

mg/dL

Cockcroft-Gault · AdjBW auto if TBW >20% above IBW · Used as fallback if no serial SCr entries below

Patient on peritoneal dialysis

Serial SCr — time-varying renal function (optional)

No SCr entries — Bayesian uses baseline SCr above

When entries are present, Bayesian uses the SCr closest in time to the last dose. Enables AKI/recovery trend detection.

Dosing course history

Doses administered

No doses — press + Add Dose

Current intended regimen

Detection runs when you calculate.

Observed vancomycin levels

No levels — press + Add Level

Levels can be drawn at any time point (not restricted to trough). More levels → narrower AUC uncertainty.

Therapeutic target

AUC₂₄ Target

mg·h/L

MIC

mg/L

ASHP/IDSA 2020: AUC₂₄ 400–600 mg·h/L · AUC/MIC ≥ 400 at MIC 1 mg/L

Results

Enter the patient, the dosing history and any measured levels, then press Run Bayesian Analysis.

An individualised fit — MAP Bayesian, against the chosen population prior
AUC₂₄ with its uncertainty, and how far the fit moved from the prior
The concentration-time profile with your measured levels on it

Levels are optional — without them this is the population estimate.

Decision support and education only — not clinically validated, and not a prescription. Clinician judgment required.

Patient demographics

Calculated weights

Saved profiles

Renal function

Regimen preferences

Current regimen

Loading dose

Drug level

Level timing

Two levels — Sawchuk-Zaske

Level 1

Level 2

Interval the levels were drawn on

Target maintenance interval

Sampling scenario

Dose given

Measured level

Target maintenance interval

Peritoneal dialysis

Dosing weight and volume

Goal level

IV doses

Levels

PK model

Therapeutic target

Results

Bayesian precision dosing

Saved profiles

Patient demographics

Renal function

Serial SCr — time-varying renal function (optional)

Dosing course history

Doses administered

Observed vancomycin levels

Haemodialysis sessions

Therapeutic target

Results

Vancomycin TDM calculator

Patient demographics

Calculated weights

Saved profiles

Renal function

Regimen preferences

Current regimen

Loading dose

Drug level

Level timing

Two levels — Sawchuk-Zaske

Level 1

Level 2

Interval the levels were drawn on

Target maintenance interval

Sampling scenario

Dose given

Measured level

Target maintenance interval

Peritoneal dialysis

Dosing weight and volume

Goal level

IV doses

Levels

PK model

Therapeutic target

Results

Bayesian precision dosing

Saved profiles

Patient demographics

Renal function

Serial SCr — time-varying renal function (optional)

Dosing course history

Doses administered

Observed vancomycin levels

Haemodialysis sessions

Therapeutic target

Results